加州大学Phillip A. Cleves小组的最新研究探明了溶酶体机制的共同选择塑造了支持珊瑚礁的细胞内光共生的进化。这一研究成果发表在2026年7月1日出版的国际学术期刊《细胞》上。

利用海葵，该课题组研究人员生成了高质量的共生体蛋白质组，揭示了共生过程中蛋白质运输机制和生物分子交换类型。溶酶体蛋白的共生体富集，溶酶体融合的可视化，以及溶酶体基因敲低后的共生减少表明，共生体通过广泛的共选择溶酶体蛋白发挥作用。该团队鉴定了一种共生体碳酸氢盐/硫酸盐转运体SLC26A11，并通过CRISPR/Cas9诱变表明，这种溶酶体转运体是Aiptasia和造礁珊瑚共生所必需的。总之，这些发现揭示了珊瑚和海葵反复选择溶酶体蛋白来浓缩碳和穿梭代谢物以支持光共生，为新的光共生的重复进化提供了一个相对简单的途径。

据了解，内共生刺激了生命中新细胞器的进化。珊瑚和其他刺胞动物反复进化出一种叫做共生体的细胞器，它与细胞内的藻类共生体同源。然而，使这种重复进化的分子机制仍然不清楚。

附：英文原文

Title: Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs

Author: Shumpei Maruyama, Catherine F. Henderson, Natalie Swinhoe, Griffin P. Kowalewski, Emily K. Meier, Ty R. Engelke, Phillip A. Cleves

Issue&Volume: 2026-07-01

Abstract: Endosymbiosis has spurred the evolution of new organelles across life. Corals and other cnidarians have repeatedly evolved an organelle, called the symbiosome, which houses intracellular algal symbionts. However, the molecular mechanisms enabling this repeated evolution remain unclear. Using the sea anemone Aiptasia, we generated a high-quality proteome of the symbiosome, revealing protein trafficking mechanisms and the types of biomolecules exchanged during symbiosis. Symbiosomal enrichment of lysosomal proteins, visualization of lysosomal fusion, and reduced symbiosis following knockdown of lysosomal genes indicate that the symbiosome functions through extensive co-option of lysosomal proteins. We identified a symbiosomal bicarbonate/sulfate transporter, SLC26A11, and showed through CRISPR/Cas9 mutagenesis that this lysosomal transporter is required for symbiosis in Aiptasia and a reef-building coral. Together, these findings reveal that corals and anemones have repeatedly co-opted lysosomal proteins to concentrate carbon and shuttle metabolites to support photosymbiosis, providing a relatively simple path for the repeated evolution of new photosymbioses.

DOI: 10.1016/j.cell.2026.06.015

Source: https://www.cell.com/cell/abstract/S0092-8674(26)00701-4

期刊信息

Cell：《细胞》，创刊于1974年。隶属于细胞出版社，最新IF：66.85

官方网址：https://www.cell.com/

投稿链接：https://www.editorialmanager.com/cell/default.aspx