英国剑桥大学Timotheus Y. F. Halim小组近日取得一项新成果。经过不懈努力，他们的论文发现了ILC2s调节胰腺中的成纤维细胞祖细胞生态位。相关论文于2026年7月2日发表于国际顶尖学术期刊《科学》杂志上。

该研究团队将2组先天淋巴样细胞（ILC2s）定义为胰腺成纤维细胞稳态的关键调节因子。ILC2s与表达Pi16+Dpp4+Ly6c+基因的成纤维细胞共定位于外分泌胰腺的间质生态位，该生态位包裹着器官实质。ILC2s特异性调节具有祖细胞能力的Pi16+Dpp4+Ly6c+成纤维细胞的扩增，同时抑制炎症期间上皮内分化的Col15a1+成纤维细胞。这些回路增强了损伤后成纤维细胞的数量，并设定了炎症阈值。ILC2和Pi16+Dpp4+Ly6c+成纤维细胞祖位在肿瘤周围扩大，并控制癌症相关成纤维细胞的发生和密度。因此，ILC2-成纤维细胞对话代表了一个局部协调组织稳态和病理的调节节点。

据了解，局部成纤维细胞的发育和密度影响器官健康和疾病，尽管目前尚不清楚组织成纤维细胞的形貌是如何原位控制的。

附：英文原文

Title: ILC2s regulate a fibroblast progenitor niche in the pancreas

Author: Thomas Yip, Julie Stockis, Charlotte Simpson, Erika E. McCartney, Shwetha Raghunathan, Martha M. Rangel-Sosa, Sydney N. Hummel, Julia Moreno-Vicente, Gianmarco Raddi, Celine Garcia, Rugile Linkute, Silvain Pinaud, Maye F. Cheng, Lesley A. Hill, T. Michael Underhill, Hans-Reimer Rodewald, Christoph Schneider, Claus Jrgensen, Andrew N.J. McKenzie, Sophie E. Acton, Patrick Seale, Menna R. Clatworthy, Matthew B. Buechler, Timotheus Y. F. Halim

Issue&Volume: 2026-07-02

Abstract: Local fibroblast development and densities influence organ health and disease, although it remains unclear how tissue fibroblast topography is controlled in situ. Here, we defined Group 2 innate lymphoid cells (ILC2s) as key regulators of fibroblast homeostasis in the pancreas. ILC2s colocalized with fibroblasts expressing the genes Pi16+Dpp4+Ly6c+ in an interstitial niche of the exocrine pancreas, which encapsulates the organ parenchyma. ILC2s specifically regulated the expansion of Pi16+Dpp4+Ly6c+ fibroblasts, which have progenitor capacity, while restraining differentiated intraparenchymal Col15a1+ fibroblasts during inflammation. These circuits reinforced fibroblast numbers after injury and set an inflammatory threshold. The ILC2 and Pi16+Dpp4+Ly6c+ fibroblast progenitor niche expanded around tumors and controlled cancer-associated fibroblast ontogeny and density. Hence, ILC2-fibroblast dialogue represents a regulatory node that locally orchestrates tissue homeostasis and pathology.

DOI: aea5113

Source: https://www.science.org/doi/10.1126/science.aea5113

期刊信息

Science：《科学》，创刊于1880年。隶属于美国科学促进会，最新IF：63.714

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