近日，华东理工大学林嘉平团队报道了多肽单锅可控自组装构建层次螺旋环体。相关论文于2025年12月23日发表在《德国应用化学》杂志上。

自组装已被证明是构建复杂层级结构的稳健策略。手性或环状纳米结构的构筑一直备受关注，然而同时兼具手性与环状特征的层级纳米结构鲜有报道，其形成机制亦不甚明晰。

研究组报道了通过多肽一锅自组装形成螺旋方向可控的环状结构。在多肽溶液中加入选择性溶剂并经透析处理后，可形成具有左手螺旋结构的均一环状体。机理分析表明，多肽先形成球形聚集体，随后在透析过程中穿孔演化为环状结构。与此同时，多肽链发生重排，实现环状体内多肽的有序堆积并形成螺旋结构。

螺旋环状体的形成可通过组装条件精确调控，其手性取决于多肽主链的本征手性。这是通过一锅自组装获得兼具多重拓扑特征层级结构的开创性实例，为构建具有手性与环状特征的复杂纳米结构提供了直接高效的新策略。

附：英文原文

Title: Hierarchical Helical Toroids Constructed from One-pot Controllable Self-Assembly of Polypeptides

Author: Wenhao Gao, Shuxiao Wang, Liang Gao, Jiaping Lin, Chunhua Cai

Issue&Volume: 2025-12-23

Abstract: Self-assembly has proven to be a robust strategy for constructing intricate hierarchical structures. The construction of chiral or toroidal nanostructures has attracted considerable attention. However, hierarchical nanostructures involving both chiral and toroidal features are rarely reported and related mechanism is less understood. Herein, we report a discovery of toroids with controllable helical senses from the one-pot self-assembly of polypeptides. Through the addition of selective solvent to polypeptide solution and the followed dialysis, uniform toroids with left-handed helical structures are formed. Mechanism analysis revealed that the polypeptides are initially assembled into spherical aggregates, then the spheres perforated into toroids during the dialysis process. Simultaneously, chain rearrangement occurs, resulting in an ordered packing of polypeptides within the toroids and the formation of helical structures. The formation of helical toroids can be well controlled by the assembly conditions, and its chirality was found to be dependent on the polypeptide backbone chirality. This is a pioneering example of one-pot self-assembly of hierarchical structures containing multiple topological features, providing a straightforward efficient strategy for constructing complicated nanostructures with chiral and toroidal features.

DOI: 10.1002/anie.202524375

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202524375